Pharmacology of Antineoplastic Agents in Older Cancer Patients
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چکیده
People over the age of 65 are a fast-growing segment of the US population, and with the incidence of cancer increasing with age, the challenges of treating older cancer patients are also on the rise. Drs. Lichtman and Skirvin present a comprehensive review of the antineoplastic agents used in elderly cancer patients. They highlight the important factors of chemotherapy pharmacology in elderly cancer patients, with emphasis on the impact of physiologic changes—especially renal clearance—in dosing and toxicity. In addition, descriptions of significant toxicities are provided. The following additional issues should be considered.
منابع مشابه
Pharmacology of Antineoplastic Agents in Older Cancer Patients
People over the age of 65 are a fast-growing segment of the US population, and with the incidence of cancer increasing with age, the challenges of treating older cancer patients are also on the rise. Drs. Lichtman and Skirvin present a comprehensive review of the antineoplastic agents used in elderly cancer patients. They highlight the important factors of chemotherapy pharmacology in elderly c...
متن کاملPharmacology of Antineoplastic Agents in Older Cancer Patients
A key issue is that most of the pharmacologic data discussed may not have been obtained in those patients who form the majority of the elderly populationat least among those over age 75ie, those with comorbidities. The authors do caution us that pharmacokinetic data in older patients are limited due to the inclusion of only a small number of these patients in studies with a wide range of ages...
متن کاملClinical Pharmacology of Chemotherapy Agents in Older People with Cancer
Populations around the world are aging, and the associated increase in cancer incidence has led to the recognition of the importance of geriatric oncology. Chronological age is a poor determinant of pharmacological response to cancer chemotherapy agents. Age-associated changes in physiology and organ function have a significant impact on the clinical pharmacology of cancer chemotherapy agents u...
متن کاملPharmacology of antineoplastic agents in older cancer patients.
Persons over the age of 65 years are the fastest growing segment of the United States population. In the next 30 years it will comprise over 20% of the population. Fifty percent of all cancers occur in this age group and therefore there will be an expected rise in the total cancer burden. Data is becoming available which will better guide the use of chemotherapy in the older patient population....
متن کاملExposure to Antineoplastic Agents Induces Cytotoxicity in Nurse Lymphocytes: Role of Mitochondrial Damage and Oxidative Stress
Cytotoxicity and mitochondrial parameters were studied in isolated lymphocytes and their mitochondria obtained from occupationally exposed nurses through inhalation exposure to antineoplastic drugs and results were compared to those of unexposed nurses. The group of occupationally exposed nurses consisted of 50 individuals ranging in age from 30 to 35 years. The control group included 50 nurses...
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تاریخ انتشار 2017